Endocrine Abstracts

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objectives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted in Orthopedic Surgery and Traumatology (OST) area.Material and methods: Descriptive analysis of patients admitted to OST Service who presented abnormally high or decreased blood g...

Introduction: Episodes of poorly controlled diabetes (DM) are one of the most frequent medical complications during hospitalization in the elderly population.Objetives: To analyze the prevalence of episodes of diabetic decompensation in patients admitted to the area of Vascular Surgery and Angiology (VS).Material and methods: Descriptive analysis of patients admitted to the VS Service who presented abnormally high or decreased bloo...

The emergence of a new generation of long-acting insulin analogues (insulin degludec -ID- and insulin glargine 300 U/ml -IG300-) has increased treatment options in type 1 diabetes (T1D), demonstrating in clinical trials better metabolic control with lower hypoglycemia rates.Objectives: To assess characteristics of T1D patients who were given ID and IG300 in clinical practice and to evaluate their effect on metabolic control, weight, insulin dose and hypo...

Objectives: To determine the habits and lifestyle of the morbidly obese before and after bariatric surgery.Material and methods: Transversal study of two groups of morbidly obese patients attending the Endocrinology Unit of Puerta del Mar, Cádiz: one group before and the other after bariatric surgery. Clinical and analytical data of the patients was collected: socio-demographic and lifestyle characteristics, Bulit-R Questionnaire (Bulimia), BIS (imp...

Introduction: DNA methylation is one of the epigenetic mechanisms existing to regulate gene expression. It is believed that methylation of DNA is susceptible of change by environmental and nutritional factors. Thus, epigenetics provides a mechanism which may explain the etiology of some metabolic disorders and obesity.Aim: The aim of this study is to analyze the DNA methylation level of several lipoprotein lipase (LPL)-promoter-CpG island in human viscer...

Introduction: Clinical observational studies have reported the persistence of a high cardiovascular risk in patients with cured Cushing’s syndrome (CCS) compared with controls of the same age, gender and BMI. It is still at debated whether this is due to the persistence of comorbidities, hormone deficiencies or chronic changes induced by hypercortisolism. The aim of this translational approach was to investigate the interplay in CCS of the cardiovascular disease in vivo a...

Objectives: To study for the first time the differences in monocyte/macrophage infiltration, inflammation and adipogenesis in the subcutaneous and visceral adipose tissues of normal-weight subjects who differed in their degree of metabolic syndrome.Methods: The study included 92 normal-weight subjects who differed in their degree of metabolic syndrome. Anthropometric and biochemical parameters were measured. RNA from subcutaneous and visceral adipose tis...

A relationship between obesity, plasma leptin concentration and primary hyperparathyroidism has been previously reported. To test the hypothesis that leptin directly stimulates parathyroid hormone (PTH) secretion, in vivo and in vitro experiments were conducted. In the in vivo studies leptin (200 μg/kg, ip) was administered to lean and obese (mutants that do not express active leptin receptor) Zucker rats. The in vitro experiments were ...

Background: Human fibroblast growth factor 21 (FGF21) is a new liver hormone that stimulate adipocyte glucose uptake and is involved in regulation of body fat.Objective: To define the natural history of FGF21 in peritoneal dialysis (PD) patients and analyze its relationship with glucose metabolism, peritoneal function, and residual renal function (RRF).Methods: We studied 48 uremic patients undergoing PD. Patients were evaluated at...

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...